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KMID : 0644319980040010199
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Journal of Korean Oriental Oncology
1998 Volume.4 No. 1 p.199 ~ p.209
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A tendency of herbal medicines on anti-viral effect
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Abstract
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In order to find antiviral effect against Human immunodeficiency virus(HIV), Herpes simplex virus type Ⅰ(HSV-1) and Ⅱ(HSV-2) from herb medicines, publicated 29 papers on anti-viral effect of herbal medicines and a convenient virus-induced cytopathic effect (CEP) inhibition assay was introduced. The major virus on experiment are HIV, Hepatitis B virus and HSV-1,2. Those of other studies showed infected virus DNA replication and screening test of herbal medicines. More than 15 extractions were prepared by pure water boiling from herbal medicines, and theor toxicity of infected cell and acti-viral activities were evaluated. Among them, the major part of herbal medicines showed cell stability compared with the contrast. Cytotoxic concentration (CC)of the H_2O extracts of Padoo against HIV sas <4.0. Hyungbangpaedoksan against HIV was 9.3. Whangyonhaedoktang against HSV-1 and HSV-2 was 15.3.
These are high level cytotoxic conentration compared with the contrast. But antivital effect was unable to figure out for selective index(SI)=CC_50/EC_50- The other herbal medicines were unable to showed potent anti-HIV and anti-HSV activity.
The antiviral activation using herbs in this thesis have unlimited objects, to select research object will help to show the dirction of antiviral drug development that have less side effect and more excellent efficiency.
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KEYWORD
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